Description: Juvenile myoclonic epilepsy (JME) is a common form of epilepsy that usually is easily controlled by treatment with Depakote (valproate) alone. The syndrome usually requires lifelong treatment but with the right choice of medications, people who have JME can live without seizures and without bothersome medication side effects. The usual effective dose for JME is from 500 to 1000 mg of Depakote per day.