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Date Submitted:
12/09/07
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Role of p47phox in Vascular Oxidative Stress and Hypertension Caused by Angiotensin II
Description:
Hypertension caused by angiotensin II is dependent on vascular superoxide (O2�-) production. The nicotinamide adenine dinucleotide phosphate (NAD[P]H) oxidase is a major source of vascular O2�- and is activated by angiotensin II in vitro. However, its role in angiotensin II-induced hypertension in vivo is less clear. In the present studies, we used mice deficient in p47phox, a cytosolic subunit of the NADPH oxidase, to study the role of this enzyme system in vivo.
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