Description: Lowe and colleagues (1) reported on long-term seizure control and quality-of-life outcomes after surgery. The special feature of this report is that the investigators included a homogeneous cohort of 50 patients with hippocampal sclerosis (verified by pathology, MRI), evaluated at least 2 years post-surgery. The long-term self-report assessment revealed seizure-freedom for 82% of patients for 1 year, 76% for 2 years, and 63% for approximately 5 years, based on the Engel Classification Grade 1 (2). Thus, although the prognosis for complete seizure control was excellent for people with this well-defined temporal lobe syndrome, a risk of recurrence remained even after 2 years of seizure freedom. Notably, the 10 patients who discontinued all medications had rare seizures or none. The higher-than-usual rates for seizure control compared to other reports are likely related to inclusion of the homogeneous population limited to hippocampal sclerosis.