Description: The two major organizations for healthcare professionals with an interest in epilepsy have come to a consensus on the use of newer antiepileptic drugs (AEDs) for new-onset epilepsy. Their report describes how they reviewed reports of clinical trials (testing in groups of patients) of the new generation of AEDs to determine whether the results support the use of each drug as first-line treatment for patients. The method, called ”evidence-based,” uses established definitions to rate the quality and reliability of “evidence” from clinical trials. The desirable “Level A” rating requires either one very well designed study or two somewhat lesser studies, all with positive results showing that the AED is effective.