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Date Submitted: 12/11/07
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Hormone Therapy for Prostate Cancer Linked to Heart Risks



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Description: TUESDAY, Oct. 9 (HealthDay News) -- Prostate cancer patients receiving androgen-deprivation therapy, a common form of hormone treatment proven to slow tumor growth and prolong life, may face a nearly threefold higher risk of dying from heart disease, a new study suggests.

The apparent danger results from a drop in testosterone levels that is central to androgen-deprivation therapy's (ADT) effectiveness at curbing prostate cancer, the study authors said.

This drop in testosterone can provoke insulin resistance, leading to type 2 diabetes, as well as a gain in body mass, body fat and so-called bad cholesterol. Collectively, this group of problems is called the "metabolic syndrome," a condition long-associated with cardiac complications.

"However, I think overall ADT does help people with prostate cancer, and until it's studied further this can't be considered proof that there's a connection between the cardiac effects and hormone therapy," said study author Dr. Henry K. Tsai, wh

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