Helix Exams

Date Submitted: 12/11/07
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HIV Drug Might Fight Cancer



Added by Bryan

Description: SATURDAY, Sept. 1 (HealthDay News) -- A drug used as part of a regimen to treat HIV also appears to kill cancer cells, researchers from the U.S. National Cancer Institute report.

Based on this new finding, the HIV protease inhibitor nelfinavir is being used in a phase I clinical trial to determine what might be the safest and most effective dose for cancer patients. This strategy of finding new uses for existing drugs could have a major impact on treating cancer and other diseases, the researchers added.

"This could be a new approach to finding cancer drugs and cut the time for getting them approved," said lead researcher Dr. Phillip A. Dennis. "Repositioning drugs that are already FDA-approved could accelerate the development of new cancer therapies."

The researchers hit upon the idea of testing nelfinavir and other protease inhibitors as cancer drugs, because these drugs block Akt, a protein essential for the development of many types of cancer, including non-small cell lung

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