Description: Status epilepticus (SE) is a medical emergency that requires rapid and aggressive treatment to prevent neuronal damage, systemic complications and death. When the seizures associated with SE do not respond to initial drug therapy; thus becoming what is known as refractory status epilepticus (RSE), clinicians are encouraged to take very aggressive treatment measures, including: coma induction and EEG suppression. But how does treatment aggressiveness affect the prognosis of RSE? This is the question Edward Bromfield, M.D, Brigham & Women’s Hospital and Harvard Medical School, Andrea Rossetti, M.D., Swiss National Science Foundation, and Giancarlo Logroscino, M.D., PhD, Harvard School of Public Health, addressed in their latest research study. They presented their findings at the American Epilepsy Society 59th Annual meeting in Washington, DC.