Description: People with Asperger's syndrome most likely have generalized alterations in brain development, but this is associated with significant differences from controls in the anatomy and function of specific brain regions implicated in behaviors characterizing the disorder. We hypothesize that Asperger's syndrome is associated with abnormalities in frontal-striatal pathways resulting in defective sensorimotor gating, and consequently characteristic difficulties inhibiting repetitive thoughts, speech, and actions.