Description: Children with various types of childhood epilepsy that do not respond to the usual seizure medicines may be candidates for treatment with adrenocorticotropic hormone or ACTH. ACTH is a first-line treatment for infantile spasms, but it is also used in Lennox-Gastaut syndrome, Landau-Kleffner syndrome, and electrical status epilepticus in sleep. Improvement in seizure control can be seen even in the most difficult-to-control epilepsy after treatment with ACTH. The child's developmental status also may improve.